RHEUZA 12 (Benzathine Penicillin)

RHEUZA 12 (Benzathine Penicillin)


Rheuza-12 is the brand name of Benzathine Penicillin (BPG) 1200000 Units Dry Powder for Injection. This antibiotic is used to treat several bacterial infections




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Rheuza-12 is the brand name of Benzathine Penicillin (BPG) 1200000 Units Dry Powder for Injection. This antibiotic is used to treat several bacterial infections

Therapeutic Class

Antibiotics ( Beta Lactam Anitbiotics)

Dose and Direction of Use

The preparation is strictly for intramuscular injection.

The injection must not be administered into tissue with reduced perfusion.

Benzathine Penicillin should be administered by deep intramuscular injection into the upper, outer quadrant of the gluteus maximus. The puncture should be as vertical to the skin surface as possible and the injection as far away from major vessels as possible. In all events, aspiration must be performed prior to the injection. If aspiration of blood or pain occurs during the injection, it must be discontinued.

For depot preparations, a total volume of 5 ml per injection site is stated as the tolerance limit. Thus, no more than 5 ml of the ready-to-inject suspension should be administered at any one time into one site.

The injection should be given as slowly as possible and only with the application of low pressure. “Rubbing” after the injection should be avoided.

Mode of Action

Penicillin binds to the transpeptidase and interferes with cross-linking of peptidoglycan thus, interfering with the cell wall synthesis. The action is bactericidal and mainly fights and stops the growth of the gram-positive type of bacteria.


To treat bacterial infections (eg, mild to moderate infections of the upper respiratory tract, syphilis, yaws, bejel, pinta). It is also used to prevent rheumatic fever, chorea, rheumatic heart disease, or acute glomerulonephritis.


Don’t use this medicine if you have:

Hypersensitivity to the active substance benzathine penicillin, to any of the penicillins, soya, peanut.
History of a severe immediate hypersensitivity reaction to another beta-lactam agent (eg cephalosporin, carbapenem or monobactam).
Precautions and Warning
The injection is for deep intramuscular only.
The penicillin sensitivity test is essential.
Careful inquiry should be made concerning previous hypersensitivity reactions to Penicillins.
It should be used with caution in patients with renal impairment, hepatic impairment and in individuals with histories of significant allergies and/or asthma.
Care should be taken to avoid intravenous or intra-arterial administration, or injection into or near major peripheral nerves or blood vessels, since such injection may produce neurovascular damage.


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